Insider Activity Lights Up Amid Angelini Merger
The July 15 filing shows Chief Human Resources Officer Russo Gregg liquidated all remaining Catalyst shares and exercised every outstanding option and restricted‑stock unit, cashing in a total of $476 shares plus the proceeds from 15 k, 6 957 k, 20 349 k, 20 531 k, 2 752 k and 6 197 k option/RSU payouts. The transaction coincides exactly with the completion of Angel Pharma’s acquisition, underscoring that the sale was part of the merger‑related settlement rather than a “personal” divestiture. Investors can view the 31.49‑dollar price as a fair‑market value for Catalyst shares on the day of the closing, given the 49.88 % year‑to‑date gain and the 18.1 price‑earnings ratio that places Catalyst just below the sector average.
What the Deal Means for Investors
The merger means Catalyst is no longer an independent public company; its shares will cease to trade on Nasdaq and the stock will be absorbed into Angel Pharma’s portfolio. For shareholders, the transaction offers an orderly exit at a premium that reflects Angel’s strategic value of Catalyst’s rare‑disease pipeline. The 0‑% price change and 981 % social‑media buzz suggest that the market was already pricing in the deal, while the high sentiment (+90) indicates strong investor confidence in the post‑merger synergy. Long‑term investors should focus on the integrated pipeline and the potential for accelerated development under Angel’s global R&D resources, rather than short‑term share price movements.
Profile of Russo Gregg – A Cautious, Long‑Term Player
Gregg’s trading history paints the picture of an insider who balances short‑term liquidity needs with a long‑term stake in the company. In February 2026, he sold 211 shares and bought 687 shares in a single filing, a net purchase that increased his holdings to 687 shares. He also liquidated a large RSU block (687 RSUs) in the same transaction, reducing his overall equity stake from 71 786 to 71 099 shares. The July 15 sale is consistent with a strategic divestiture triggered by a corporate event rather than a confidence‑draining move. Historically, Gregg has avoided large, frequent trades, suggesting a focus on stable employment value and alignment with senior management.
Insider Trends Across the Board
The July 15 wave of sales is not unique to Gregg. Senior executives such as Daly J., Elsbernd B., and Sundaram P. all sold massive blocks of common stock and options, totaling several million shares and options. This coordinated selling is typical in a merger where the acquirer pays cash or stock‑based consideration that satisfies liquidity for senior management. For the remaining minority shareholders, the key takeaway is that the company’s strategic direction is now locked into Angel Pharma’s broader brain‑health agenda, with Catalyst’s research pipeline expected to benefit from increased funding and global reach.
Bottom Line
The insider activity surrounding Russo Gregg’s sale and the broader sell‑off by senior management signal the completion of a major corporate transaction rather than an erosion of confidence. Investors looking ahead should track how Catalyst’s therapeutic candidates integrate into Angel Pharma’s portfolio and monitor post‑merger performance metrics, such as R&D milestones and market expansion, to gauge the long‑term upside of this acquisition.
| Date | Owner | Transaction Type | Shares | Price per Share | Security |
|---|---|---|---|---|---|
| 2026-07-15 | Russo Gregg (Chief HR Officer) | Sell | 476.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Russo Gregg (Chief HR Officer) | Sell | 15,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Russo Gregg (Chief HR Officer) | Sell | 6,957.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Russo Gregg (Chief HR Officer) | Sell | 20,349.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Russo Gregg (Chief HR Officer) | Sell | 20,531.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Russo Gregg (Chief HR Officer) | Sell | 2,752.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Russo Gregg (Chief HR Officer) | Sell | 6,197.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Tierney David S () | Sell | 383,314.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Tierney David S () | Sell | 33,500.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Tierney David S () | Sell | 30,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Tierney David S () | Sell | 20,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Tierney David S () | Sell | 15,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Tierney David S () | Sell | 29,524.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Tierney David S () | Sell | 23,248.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Tierney David S () | Sell | 18,115.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Tierney David S () | Sell | 1,414.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Tierney David S () | Sell | 1,894.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Tierney David S () | Sell | 5,468.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Curran Daniel J. () | Sell | 40,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Curran Daniel J. () | Sell | 18,115.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Curran Daniel J. () | Sell | 5,468.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 242,501.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 132,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 200,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 135,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 69,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 147,621.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 126,704.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 98,652.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 7,067.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 10,322.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Elsbernd Brian (Chief Legal Officer) | Sell | 29,776.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 271,266.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 33,500.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 30,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 20,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 15,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 1,365,319.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 491,160.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 381,948.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 126,316.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 40,013.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Daly Richard J (President and CEO) | Sell | 115,283.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Sundaram Preethi (Chief Strategy Officer) | Sell | 54,804.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Sundaram Preethi (Chief Strategy Officer) | Sell | 225,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Sundaram Preethi (Chief Strategy Officer) | Sell | 67,500.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Sundaram Preethi (Chief Strategy Officer) | Sell | 68,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Sundaram Preethi (Chief Strategy Officer) | Sell | 143,193.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Sundaram Preethi (Chief Strategy Officer) | Sell | 137,553.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Sundaram Preethi (Chief Strategy Officer) | Sell | 106,873.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Sundaram Preethi (Chief Strategy Officer) | Sell | 6,855.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Sundaram Preethi (Chief Strategy Officer) | Sell | 11,206.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Sundaram Preethi (Chief Strategy Officer) | Sell | 32,257.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 14,337.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 150,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 200,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 135,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 88,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 167,918.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 137,553.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 106,873.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 8,039.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 11,206.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Del Carmen Jeffrey (Chief Commercial Officer) | Sell | 32,257.00 | N/A | Restricted Stock Units |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 4,171,559.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 740,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 400,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 270,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 272,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 73,810.00 | N/A | Options to purchase common stock |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 43,591.00 | N/A | Options to purchase common stock |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 34,921.00 | N/A | Options to purchase common stock |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 3,534.00 | N/A | Restricted Stock Units |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 3,552.00 | N/A | Restricted Stock Units |
| 2026-07-15 | MCENANY PATRICK J () | Sell | 10,540.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Thompson Tamar () | Sell | 3,773.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Thompson Tamar () | Sell | 40,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Thompson Tamar () | Sell | 29,524.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Thompson Tamar () | Sell | 23,248.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Thompson Tamar () | Sell | 18,115.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Thompson Tamar () | Sell | 1,414.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Thompson Tamar () | Sell | 1,894.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Thompson Tamar () | Sell | 5,468.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 1,093,803.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 180,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 275,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 185,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 146,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 248,004.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 202,958.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 158,454.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 11,873.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 16,534.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Miller Steve (Chief Op. & Scientific Officer) | Sell | 47,826.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Kalb Michael Wayne (Chief Financial Officer) | Sell | 13,665.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Kalb Michael Wayne (Chief Financial Officer) | Sell | 257,214.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Kalb Michael Wayne (Chief Financial Officer) | Sell | 169,248.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Kalb Michael Wayne (Chief Financial Officer) | Sell | 131,536.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Kalb Michael Wayne (Chief Financial Officer) | Sell | 21,416.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Kalb Michael Wayne (Chief Financial Officer) | Sell | 13,788.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Kalb Michael Wayne (Chief Financial Officer) | Sell | 39,701.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Harper Molly () | Sell | 3,694.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Harper Molly () | Sell | 12,500.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Harper Molly () | Sell | 20,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Harper Molly () | Sell | 15,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Harper Molly () | Sell | 29,524.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Harper Molly () | Sell | 23,248.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Harper Molly () | Sell | 18,115.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Harper Molly () | Sell | 1,414.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Harper Molly () | Sell | 1,894.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Harper Molly () | Sell | 5,468.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Andrews William T. (Chief Medical Officer) | Sell | 2,309.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | Andrews William T. (Chief Medical Officer) | Sell | 124,447.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Andrews William T. (Chief Medical Officer) | Sell | 98,652.00 | N/A | Options to purchase common stock |
| 2026-07-15 | Andrews William T. (Chief Medical Officer) | Sell | 12,209.00 | N/A | Restricted Stock Units |
| 2026-07-15 | Andrews William T. (Chief Medical Officer) | Sell | 29,776.00 | N/A | Restricted Stock Units |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 498,773.00 | 31.50 | Common Stock, par value $0.001 per share |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 33,500.00 | N/A | Options to purchase common stock |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 30,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 20,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 15,000.00 | N/A | Options to purchase common stock |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 29,524.00 | N/A | Options to purchase common stock |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 23,248.00 | N/A | Options to purchase common stock |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 18,115.00 | N/A | Options to purchase common stock |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 1,414.00 | N/A | Restricted Stock Units |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 1,894.00 | N/A | Restricted Stock Units |
| 2026-07-15 | DENKHAUS DONALD A () | Sell | 5,468.00 | N/A | Restricted Stock Units |




